Cryptic crossword clue
Nasty persons spreading bile are to blame 11

The most common and most likely answer to this crossword clue is the 11 letter word RESPONSIBLE

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More clues leading to the result RESPONSIBLE

Buddy explains!

The straight part
We know that "to blame" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case to blame = responsible.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

Crossword Answer definitions

RESPONSIBLE noun
  1. The individual who bears the responsibility for something.
  2. An actor taking on the lesser roles in repertory theatre.
RESPONSIBLE adjective
  1. (followed by "for") Having the duty of taking care of something; answerable for an act performed or for its consequences; accountable; amenable, especially legally or politically.
  2. (followed by "for") Being a primary cause of a situation or action and thus able to be blamed or credited for it.
  3. (followed by "to") Answerable to (a superior).
  4. (of a job or position) Involving important duties; involving a degree of personal accountability on the part of the person concerned.
  5. Having good judgment in decision-making.
  6. Able to be trusted; reliable; trustworthy.
  7. Capable of rational conduct and thus morally accountable for one's behavior.

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