The most common and most likely answer to this crossword clue is the 4 letter word ERIE
E
R
I
E
More clues leading to the result ERIE
- Mere daydream, but vicar’s drifted off
- Lake that sounds spooky
- Lake one has gone in before, once
- Native Americans seeing bear-like characters every so often
- Lake where exclusive circle get rid of bed
- Lake near river, oddly drained
- Osprey finally leaves nest for lake
- Lake Ireland viewed from the south?
- Personification of QE2 that is seen in lake
- One of the Great Lakes up-country?
Buddy explains!

The straight part
We know that "Native Americans" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case native americans = erie.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.