The most common and most likely answer to this crossword clue is the 2 plus 6 letter word OF COURSE
I've seen this crossword clue in The Guardian
O
F
C
O
U
R
S
E
More clues leading to the result OF COURSE
- Certainly old, refocus after treatment
- Clearly prof ignoring PR lessons
- Starters for our first part of meal, naturally
- naturally
- Dynamic forces around Open University, certainly
- End this is when 30 is given naturally
- Surely deviating from the correct route, one fellow’s lost
- Sure about supporting football club during no-score draw? Yes, sure
- Definitely from St Andrews?
- In Troon, take out good new driver by all means
Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.