The most common and most likely answer to this crossword clue is the 3 plus 2 plus 1 plus 5 plus 4 letter word MAD AS A MARCH HARE
I've seen this crossword clue in The Daily Telegraph
M
A
D
A
S
A
M
A
R
C
H
H
A
R
E
More clues leading to the result MAD AS A MARCH HARE
Buddy explains!

The straight part
We know that "terribly, terribly crazy" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case terribly, terribly crazy = mad as a march hare.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.