Cryptic crossword clue
Nearly negate onset of Rickettsial disease  6

The most common and most likely answer to this crossword clue is the 6 letter word CANCER

C
A
N
C
E
R

Buddy explains!

The straight part
We know that "disease" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case disease = cancer.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CANCER mean?

CANCER noun
  1. A disease in which the cells of a tissue undergo uncontrolled (and often rapid) proliferation.
  2. Something damaging that spreads throughout something else.

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