Cryptic crossword clue
Needs Durex desperately in this state? Hardly! 10

The most common and most likely answer to this crossword clue is the 10 letter word UNDERSEXED

I've seen this crossword clue in The Guardian
U
N
D
E
R
S
E
X
E
D

Buddy explains!

The straight part
We know that "this state" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case this state = undersexed.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does UNDERSEXED mean?

UNDERSEXED adjective
  1. Lacking sufficient sexual desire or activity; sexually unfulfilled; sexually frustrated.

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