Cryptic crossword clue
Ne’er-do-well son in clutches of drink 6

The most common and most likely answer to this crossword clue is the 6 letter word WASTER

W
A
S
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R

Buddy explains!

The straight part
We know that "Ne’er-do-well" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case ne’er-do-well = waster.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does WASTER mean?

WASTER noun
  1. Someone or something that wastes; someone who squanders or spends extravagantly.
  2. An imperfection in the wick of a candle, causing it to waste.
  3. A destroyer.
  4. An item that is spoiled during its manufacture.
WASTER noun
  1. A kind of cudgel; also, a blunt-edged sword used as a foil.
  2. A leister; a spear for catching fish.

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