Cryptic crossword clue
Negative response from Guthrum oddly ignored Henry 2-2

The most common and most likely answer to this crossword clue is the 2 letter word UH

I've seen this crossword clue in The Times
U
H

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The straight part
We know that "Negative response" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case negative response = uh.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does UH mean?

UH noun
  1. An occurrence of the interjection "uh".
UH interjection
  1. Expression of thought, confusion, or uncertainty.
  2. Space filler or pause during conversation.

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