Cryptic crossword clue
Negative response to request for lift? 6,4

The most common and most likely answer to this crossword clue is the 6 plus 4 letter word THUMBS DOWN

I've seen this crossword clue in The Daily Telegraph
T
H
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M
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N

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does THUMBS DOWN mean?

THUMBS DOWN noun
  1. A gesture signifying disapproval; a thumb pointing down out of a fist.
  2. A rejection or refusal.
THUMBS DOWN verb
  1. To disapprove with a thumbs-down sign.

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