Cryptic crossword clue
New Republican First Lady’s given up? I don’t believe it!

The most common and most likely answer to this crossword clue is the 6 letter word NEVER!

I've seen this crossword clue in The Guardian
N
E
V
E
R
!

Buddy explains!

The straight part
We know that "I don’t believe it!" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case i don’t believe it! = never!.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NEVER! mean?

NEVER! adverb
  1. At no time; on no occasion; in no circumstance.
  2. Not at any other time; not on any other occasion; not previously.
  3. Negative particle (used to negate verbs in the simple past tense; also used absolutely).

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