Cryptic crossword clue
Newcastle area of the country? Not right at first to be nervy 6

The most common and most likely answer to this crossword clue is the 6 letter word NEURAL

I've seen this crossword clue in Independent
N
E
U
R
A
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Buddy explains!

The straight part
We know that "nervy" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case nervy = neural.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NEURAL mean?

NEURAL adjective
  1. Of, or relating to the nerves, neurons or the nervous system.
  2. Modelled on the arrangement of neurons in the brain.

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