The most common and most likely answer to this crossword clue is the 2 letter word OP
O
P
More clues leading to the result OP
Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does OP mean?
OP noun- An operation.
- An amateur radio operator.
- An operator on IRC, who can moderate the chat channel, ban users, etc.
- Op art; a style of abstract art.
- To promote (an IRC user) to an operator.
- Initialism of Overall Position.
- Initialism of online pharmacy.
- Initialism of opposite prompt; stage right,
- Initialism of original poster; the person who started a thread.
- Initialism of original post.
- Initialism of opening theme.
- A lookout or vantage point
- The credits shown at the beginning of a film, TV program, etc.
- Any ester of phosphoric acid or its derivatives, especially one used as an insecticide or herbicide.