The most common and most likely answer to this crossword clue is the 10 letter word VARIATIONS
I've seen this crossword clue in The Guardian
V
A
R
I
A
T
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More clues leading to the result VARIATIONS
Buddy explains!

The straight part
We know that "changes" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case changes = variations.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does VARIATIONS mean?
VARIATIONS noun- The act of varying; a partial change in the form, position, state, or qualities of a thing.
- A related but distinct thing.
- The angular difference at the vessel between the direction of true north and magnetic north.
- A line of play that differs from the original.
- A technique where material is repeated with alterations to the melody, harmony, rhythm, timbre, texture, counterpoint or orchestration; but with some invariant characteristic, e.g. a ground bass.
- The modification of a hereditary trait.
- Deviation from the mean orbit of a heavenly body.