The most common and most likely answer to this crossword clue is the 8 letter word MISTRUST
I've seen this crossword clue in The Times
M
I
S
T
R
U
S
T
More clues leading to the result MISTRUST
- No confidence water vapour leads to corrosion
- Be suspicious of some nonconformist rusticated
- Be wary of banal truism written by saint
- Suspect type of card set up with credit
- Doubt report that girl was tied up
- Suspicion of second financial arrangement underpinning motorway
- Spray disease of plant that’s suspect
- Spray coat produced by damp suspect
- Suspect source of damp and decay
- Suspicion of corrosion after condensation
Buddy explains!

The straight part
We know that "No confidence" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case no confidence = mistrust.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does MISTRUST mean?
MISTRUST noun- Lack of trust or confidence; distrust, untrust.
- To have no confidence in (something or someone).
- To be wary, suspicious or doubtful of (something or someone).
- To suspect, to imagine or suppose (something) to be the case.
- To be suspicious.