Cryptic crossword clue
No end of ballyhoo, no nervous reaction that’s sleep-inducing 8

The most common and most likely answer to this crossword clue is the 8 letter word HYPNOTIC

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The cryptic/wordplay part
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This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does HYPNOTIC mean?

HYPNOTIC noun
  1. A person who is, or can be, hypnotized.
  2. A soporific substance.
HYPNOTIC adjective
  1. Of, or relating to hypnosis or hypnotism.
  2. (pharmaceutical effect) Inducing sleep; soporific.

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