The most common and most likely answer to this crossword clue is the 4 letter word CASH
I've seen this crossword clue in The Guardian
C
A
S
H
More clues leading to the result CASH
Buddy explains!

The straight part
We know that "what’s missing in it" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case what’s missing in it = cash.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does CASH mean?
CASH noun- Money in the form of notes/bills and coins, as opposed to cheques/checks or electronic transactions.
- Liquid assets, money that can be traded quickly, as distinct from assets that are invested and cannot be easily exchanged.
- Money.
- Cash register.
- An instance of winning a cash prize.
- A place where money is kept, or where it is deposited and paid out; a money box.
- To exchange (a check/cheque) for money in the form of notes/bills.
- To obtain a payout from a tournament.
- Great; excellent; cool.
- Any of several low-denomination coins of India, China, or Vietnam, especially the Chinese copper coin.
- To disband. To do away with, kill