Cryptic crossword clue
No good going between two little women in system requiring one only! 8

The most common and most likely answer to this crossword clue is the 8 letter word MONOGAMY

I've seen this crossword clue in The Guardian
M
O
N
O
G
A
M
Y

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MONOGAMY mean?

MONOGAMY noun
  1. A form of sexual bonding involving a permanent pair bond between two beings.
  2. The practice of being married to one person as opposed to multiple.

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