The most common and most likely answer to this crossword clue is the 12 letter word ACQUIESCENCE
I've seen this crossword clue in The Times
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More clues leading to the result ACQUIESCENCE
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The straight part
We know that "submission" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case submission = acquiescence.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ACQUIESCENCE mean?
ACQUIESCENCE noun- A silent or passive assent or submission, or a submission with apparent content, distinguished from avowed consent on the one hand, and on the other, from opposition or open discontent; quiet satisfaction.
- Inaction, passivity, or neglect to take legal action when it is called for in order to assert, preserve, or safeguard a right, and which inaction implies the abandonment of said right.