Cryptic crossword clue
No thumbs up, that is, for relations 6

The most common and most likely answer to this crossword clue is the 6 letter word NOOKIE

I've seen this crossword clue in Financial Times
N
O
O
K
I
E

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NOOKIE mean?

NOOKIE noun
  1. Sexual intercourse or other sexual activity, especially if illicit.
NOOKIE noun
  1. A pacifier.

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