Cryptic crossword clue
Noise better when ends cut off instrument

The most common and most likely answer to this crossword clue is the 7 letter word PIPETTE

I've seen this crossword clue in The Guardian
P
I
P
E
T
T
E


Buddy explains!

The straight part
We know that "instrument" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case instrument = pipette.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PIPETTE mean?

PIPETTE noun
  1. A small tube, often with an enlargement or bulb in the middle, and usually graduated, used for transferring or delivering measured quantities of a liquid.
PIPETTE verb
  1. To transfer or measure the volume of a liquid using a pipette.

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