The most common and most likely answer to this crossword clue is the 6 letter word INSURE
I've seen this crossword clue in The Daily Telegraph
I
N
S
U
R
E
More clues leading to the result INSURE
Buddy explains!

The straight part
We know that "guarantee" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case guarantee = insure.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does INSURE mean?
INSURE verb- To make a pledge to (someone); to promise, guarantee (someone of something); to assure.
- To make sure or certain of something (usually some future event or condition).
- To provide for compensation if some specified risk occurs. Often agreed by policy (contract) to offer financial compensation in case of an accident, theft or other undesirable event.
- To deal in such contracts; subscribe to a policy of insurance