Cryptic crossword clue
Not a soul with energy after midday 2,3

The most common and most likely answer to this crossword clue is the 2 plus 3 letter word NO ONE

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Buddy explains!

The straight part
We know that "Not a soul" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case not a soul = no one.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NO ONE mean?

NO ONE pronoun
  1. Used in contrast to anyone, someone or everyone: not one person; nobody.

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