Cryptic crossword clue
Not at all prudent, following a word of rejection 6

The most common and most likely answer to this crossword clue is the 6 letter word NOWISE

I've seen this crossword clue in Financial Times
N
O
W
I
S
E

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NOWISE mean?

NOWISE adverb
  1. (In) no way, (in) no manner, definitely not.

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