The most common and most likely answer to this crossword clue is the 10 letter word INSENSIBLE
I've seen this crossword clue in The Daily Telegraph
I
N
S
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Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does INSENSIBLE mean?
INSENSIBLE adjective- Unable to be perceived by the senses.
- Incapable or deprived of physical sensation.
- Unable to be understood; unintelligible.
- Not sensible or reasonable; meaningless.
- Incapable of mental feeling; indifferent.
- Incapable of emotional feeling; callous; apathetic.