The most common and most likely answer to this crossword clue is the 3 plus 2 plus 2 letter word OUT OF IT
I've seen this crossword clue in Financial Times
O
U
T
O
F
I
T
More clues leading to the result OUT OF IT
- Toot if upset about university under influence of drugs?
- Rejected set of clothes Oscar collected
- Oscar's involved in business concern? The opposite
- Bombed, if ordered up initially to attack
- Excluded group admits nothing
- Not knowing what is happening about old clothes
- Ripped clothes worn by Oscar
- Drunk, vermouth bottle empty?
- Forbidden love? Right to get intoxicated
- Excluded over infiltrating organisation
Buddy explains!

The straight part
We know that "Not knowing what is happening" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case not knowing what is happening = out of it.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.