Cryptic crossword clue
Not prepared to mess with quartet of females? Touché! 3,3,4

The most common and most likely answer to this crossword clue is the 3 plus 3 plus 4 letter word OFF THE CUFF

I've seen this crossword clue in The Times
O
F
F
T
H
E
C
U
F
F


Buddy explains!

The straight part
We know that "Not prepared" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case not prepared = off the cuff.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does OFF THE CUFF mean?

OFF THE CUFF adjective
  1. Extemporaneous; without prior preparation; spontaneous; impromptu.

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