The most common and most likely answer to this crossword clue is the 1 plus 12 letter word A THOUSANDFOLD
A
T
H
O
U
S
A
N
D
F
O
L
D
Buddy explains!
The straight part
We know that "masses" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case masses = a thousandfold.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.