Cryptic crossword clue
Note by very loud singer at first is annoying 5

The most common and most likely answer to this crossword clue is the 5 letter word MIFFS

M
I
F
F
S

Buddy explains!

The straight part
We know that "is annoying" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case is annoying = miffs.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MIFFS mean?

MIFFS noun
  1. A small argument; a quarrel.
  2. A state of being offended.
MIFFS verb
  1. (usually used in the passive) To offend slightly.
  2. To become slightly offended.

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