The most common and most likely answer to this crossword clue is the 8 letter word LINGUINE
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More clues leading to the result LINGUINE
Buddy explains!

The straight part
We know that "Note, going round Siena, grub regularly seen?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case note, going round siena, grub regularly seen? = linguine.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does LINGUINE mean?
LINGUINE noun- Ribbons of pasta, cut from a sheet, not as wide as tagliatelle.