Cryptic crossword clue
Note touch of venom in Cleese being funny in a discriminating way 9

The most common and most likely answer to this crossword clue is the 9 letter word SELECTIVE

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Buddy explains!

The straight part
We know that "in a discriminating way" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case in a discriminating way = selective.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SELECTIVE mean?

SELECTIVE adjective
  1. Of or relating to the process of selection.
  2. Of or relating to natural selection.
  3. (of a person) choosy, fussy or discriminating when selecting.
  4. Having the authority or capability to make a selection.

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