The most common and most likely answer to this crossword clue is the 8 letter word AEGROTAT
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More clues leading to the result AEGROTAT
Buddy explains!

The straight part
We know that "evidence of malaise at Oxford" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case evidence of malaise at oxford = aegrotat.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does AEGROTAT mean?
AEGROTAT noun- A certificate indicating that a student is ill, excusing attendance at lectures and examinations and allowing courses to be passed without finishing the work.
- An unclassified degree awarded to such a student.