Cryptic crossword clue
Nothing inside box's first drawer 10

The most common and most likely answer to this crossword clue is the 10 letter word CARTOONIST

C
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T
O
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Buddy explains!

The straight part
We know that "drawer" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case drawer = cartoonist.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CARTOONIST mean?

CARTOONIST noun
  1. One who creates a cartoon or strip cartoon.
  2. One who both writes and illustrates comic books or graphic novels.

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