Cryptic crossword clue
Notice star leading fashion, upright character being held in high regard 10

The most common and most likely answer to this crossword clue is the 10 letter word ADMIRATION

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Buddy explains!

The straight part
We know that "high regard" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case high regard = admiration.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ADMIRATION mean?

ADMIRATION noun
  1. A positive emotion including wonder and approbation; the regarding of another as being wonderful
  2. Wondering or questioning (without any particular positive or negative attitude to the subject).
  3. Cause of admiration; something to excite wonder, or pleased surprise.

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