The most common and most likely answer to this crossword clue is the 5 letter word SPEKE
I've seen this crossword clue in The Guardian
S
P
E
K
E
Buddy explains!
The straight part
We know that "Now 6 across 22 across 2 keeps going off (5)" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case now 6 across 22 across 2 keeps going off (5) = speke.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.