Cryptic crossword clue
Now and then determined to hold tailless insect 12

The most common and most likely answer to this crossword clue is the 12 letter word INTERMITTENT

I've seen this crossword clue in The Guardian
I
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Buddy explains!

The straight part
We know that "Now and then" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case now and then = intermittent.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INTERMITTENT mean?

INTERMITTENT noun
  1. An intermittent fever or disease.
INTERMITTENT adjective
  1. Stopping and starting, occuring, or presenting at intervals; coming after a particular time span.
  2. (specifically, of a body of water) Existing only for certain seasons; that is, being dry for part of the year.

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