The most common and most likely answer to this crossword clue is the 3 plus 2 letter word HOP IT
H
O
P
I
T
More clues leading to the result HOP IT
- Very keen about displaying religious attitude? Get away!
- Leave work during strike
- Go away from house with depression
- Go – like a rabbit?
- Leave house and topple over
- Get out good fashionable clothes
- Work during strike or go away
- Surgery collision cases do one!
- Bound to have sex and then withdraw
- Leave work box outside
Buddy explains!

The straight part
We know that "Now shift" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case now shift = hop it.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.