Cryptic crossword clue
Nuclear device‘s designer about to be demoted 7

The most common and most likely answer to this crossword clue is the 7 letter word REACTOR

I've seen this crossword clue in Independent
R
E
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Buddy explains!

The straight part
We know that "Nuclear device" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case nuclear device = reactor.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does REACTOR mean?

REACTOR noun
  1. A person who responds to a suggestion, stimulation or other influence.
  2. (industrial) A structure used to contain chemical or other reactions.
  3. A device which uses atomic energy to produce heat.
  4. A chemical substance which responds to the presence or contact with another substance.

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