Cryptic crossword clue
Nuisance is removed with subtlety

The most common and most likely answer to this crossword clue is the 6 letter word NUANCE

I've seen this crossword clue in The Guardian
N
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A
N
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Buddy explains!

The straight part
We know that "subtlety" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case subtlety = nuance.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NUANCE mean?

NUANCE noun
  1. A minor distinction.
  2. Subtlety or fine detail.
NUANCE verb
  1. To apply a nuance to; to change or redefine in a subtle way.

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