Cryptic crossword clue
Number expected to seize large lump 6

The most common and most likely answer to this crossword clue is the 6 letter word NODULE

I've seen this crossword clue in Independent
N
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The straight part
We know that "lump" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case lump = nodule.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NODULE mean?

NODULE noun
  1. A rounded mass or irregular shape; a little knot or lump.

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