Cryptic crossword clue
Number in favour of second man being given a hearing 8

The most common and most likely answer to this crossword clue is the 8 letter word PROCAINE

I've seen this crossword clue in The Times
P
R
O
C
A
I
N
E

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The straight part
We know that "Number" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case number = procaine.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PROCAINE mean?

PROCAINE noun
  1. A drug used as a local anaesthetic.

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