Cryptic crossword clue
Number of people misspelling me in a concoction of spelling? 10

The most common and most likely answer to this crossword clue is the 10 letter word POPULATION

I've seen this crossword clue in The Guardian
P
O
P
U
L
A
T
I
O
N

Buddy explains!

The straight part
We know that "Number of people" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case number of people = population.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does POPULATION mean?

POPULATION noun
  1. The people living within a political or geographical boundary.
  2. (by extension) The people with a given characteristic.
  3. A count of the number of residents within a political or geographical boundary such as a town, a nation or the world.
  4. A collection of organisms of a particular species, sharing a particular characteristic of interest, most often that of living in a given area.
  5. A group of units (persons, objects, or other items) enumerated in a census or from which a sample is drawn.
  6. The act of filling initially empty items in a collection.

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