Cryptic crossword clue
Number one tube network in old city 6

The most common and most likely answer to this crossword clue is the 6 letter word URETER

U
R
E
T
E
R

Buddy explains!

The straight part
We know that "Number one tube" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case number one tube = ureter.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

Crossword Answer definitions

URETER noun
  1. Either of the two long, narrow ducts that carry urine from the kidneys to the urinary bladder.

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