The most common and most likely answer to this crossword clue is the 5 letter word ISSUE
I've seen this crossword clue in The Times
I
S
S
U
E
More clues leading to the result ISSUE
- Children that might be taken in disagreement?
- Problem children
- A bone to pick with children?
- Number one's appeal
- Edition is, of course, not right
- Broadcast brings controversy
- Children that may be taken where there's disagreement?
- Question paper — time running out
- Independent solicitor's first to prosecute children
- One’s bound to avoid Republican family
Buddy explains!

The straight part
We know that "Number" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case number = issue.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ISSUE mean?
ISSUE noun- The action or an instance of flowing or coming out, an outflow, particularly:
- Someone or something that flows out or comes out, particularly:
- The means or opportunity by which something flows or comes out, particularly:
- The place where something flows or comes out, an outlet, particularly:
- The action or an instance of sending something out, particularly:
- Any question or situation to be resolved, particularly:
- The action or an instance of concluding something, particularly:
- The end result of an event or events, any result or outcome, particularly:
- The action or an instance of feeling some emotion.
- The action or an instance of leaving any state or condition.
- To flow out, to proceed from, to come out or from.
- To rush out, to sally forth.
- To extend into, to open onto.
- To turn out in a certain way, to result in.
- To come to a point in fact or law on which the parties join issue.
- To send out; to put into circulation.
- To deliver for use.
- To deliver by authority.