The most common and most likely answer to this crossword clue is the 5 letter word TIGON
I've seen this crossword clue in The Times
T
I
G
O
N
More clues leading to the result TIGON
- Cross when hearing match lost
- Hybrid thing born oddly
- Animal, possibly from Bangkok, extinct, reportedly
- Cross about flipping fool taking precedence
- Number present, parting with fine, about to get cross
- Can hosts become cross?
- Cross: a little indignant, I go nuts!
- Cross, tense and nearly going nuts
- Reportedly Asian left, cross
- No unpleasant type rejected an unusual cat
Buddy explains!

The straight part
We know that "cross" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case cross = tigon.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does TIGON mean?
TIGON noun- A cross between a male tiger and a lioness.