Cryptic crossword clue
Numbers game played with iPad, rules added 9

The most common and most likely answer to this crossword clue is the 9 letter word EPIDURALS

I've seen this crossword clue in The Guardian
E
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Buddy explains!

The straight part
We know that "Numbers" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case numbers = epidurals.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

Crossword Answer definitions

EPIDURALS noun
  1. An injection of anaesthetic into the epidural space of the spine, especially associated with pain relief during childbirth.

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