The most common and most likely answer to this crossword clue is the 4 letter word TENS
I've seen this crossword clue in The Times
T
E
N
S
More clues leading to the result TENS
Buddy explains!

The straight part
We know that "Numbers" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case numbers = tens.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does TENS mean?
TENS noun- A set or group with ten elements.
- A card in a given suit with a value of ten.
- A denomination of currency, such as a banknote, with a value of ten units. See also tenner.
- A perfect specimen, a physically attractive person.
- A high level of intensity.
- The act of rowing ten strokes flat out.
- A pair of tens.
- The second decade of a century: the 1910s, 2010s, etc. The teens, the oneties.