Cryptic crossword clue
Nun departs, running amok in knickers 10

The most common and most likely answer to this crossword clue is the 10 letter word UNDERPANTS

I've seen this crossword clue in Financial Times
U
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The straight part
We know that "knickers" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case knickers = underpants.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

Crossword Answer definitions

UNDERPANTS noun
  1. Underwear covering the genitalia and often buttocks, usually going no higher than the navel.

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