Cryptic crossword clue
Nurse with spirit sat on top of express locomotive 6

The most common and most likely answer to this crossword clue is the 6 letter word ENGINE

I've seen this crossword clue in Independent
E
N
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Buddy explains!

The straight part
We know that "locomotive" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case locomotive = engine.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ENGINE mean?

ENGINE noun
  1. A large construction used in warfare, such as a battering ram, catapult etc.
  2. A tool; a utensil or implement.
  3. A complex mechanical device which converts energy into useful motion or physical effects.
  4. A person or group of people which influence a larger group; a driving force.
  5. The part of a car or other vehicle which provides the force for motion, now especially one powered by internal combustion.
  6. A self-powered vehicle, especially a locomotive, used for pulling cars along a track.
  7. A software or hardware system responsible for a specific technical task (usually with qualifying word).
  8. Ingenuity; cunning, trickery, guile.
  9. The result of cunning; something ingenious, a contrivance; (in negative senses) a plot, a scheme.
  10. Natural talent; genius.
  11. Anything used to effect a purpose; any device or contrivance; an agent.
ENGINE verb
  1. To equip with an engine; said especially of steam vessels.
  2. To assault with an engine.
  3. To contrive; to put into action.
  4. To rack; to torture.

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