Cryptic crossword clue
Nuts?  Mine are shot and they can’t multiply

The most common and most likely answer to this crossword clue is the 11 letter word INNUMERATES

I've seen this crossword clue in Independent
I
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Buddy explains!

The straight part
We know that "they can’t multiply" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case they can’t multiply = innumerates.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INNUMERATES mean?

INNUMERATES noun
  1. One who lacks numeracy skills.

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