Cryptic crossword clue
O Little Town, sung to baby ox, ends in trouble 6

The most common and most likely answer to this crossword clue is the 6 letter word OXYGEN

I've seen this crossword clue in The Guardian
O
X
Y
G
E
N


Buddy explains!

The straight part
We know that "O" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case o = oxygen.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does OXYGEN mean?

OXYGEN noun
  1. The chemical element (symbol O) with an atomic number of 8 and relative atomic mass of 15.9994. It is a colorless and odorless gas.
  2. Molecular oxygen (O2), a colorless, odorless gas at room temperature, also called dioxygen.
  3. A mixture of oxygen and other gases, administered to a patient to help them breathe.
  4. An atom of this element.

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